Building a Better Immunity: A Pathway to Healthy Longevity

PAHO carried out  the webinar "Building Better Immunity: A Path to Healthy Longevity." This event discussed the implications for the present and future of the life course approach in medicine and public health, as well as to better understand the existing applications of this approach to immunization programs in the region and the world.

Event Video

Since the second half of the 20th century, life lifespan has increased by more than 20 years. In the Americas, it is projected that nearly 80% of people born today will live more than 60 years, and approximately 40% are expected to live more than 80 years. With this trend in motion, the concept of the democratization of longevity is competing with the “natural selection” process. It tests the capacity of individual and population immunity to protect the life course.

Today, when life expectancy has almost doubled, and the world is facing a rapid demographic transition, a person’s immune system is remodeled in older age. With time, this leads to a decline in immune efficacy, resulting in increased vulnerability to infectious diseases, diminished responses to vaccination, and susceptibility to age-related inflammatory diseases.

The life course approach to immunization considers immunity as a health feature and an evolving capacity that develops dynamically over time and across generations. Immunization focuses on maximizing healthy life trajectories as its objective, protecting individuals during important life transitions and identifying critical moments across the life span where certain interventions have higher long-term efficacy.

Through immunization, the health of individuals can be maximized at each stage of the life course, not only by preventing specific infectious diseases but by training the plasticity and resilience of the immune system to develop long-lasting positive effects for individuals. These individual benefits accumulate to produce society-wide impacts on health and economies, with an intergenerational influence. Immunization is a public health intervention (including immunotherapies) that can be adjusted to close the immunity gaps of each age group, thus reducing the impact of disease and increasing the body’s capacity for health until very late in life.